Bridging single-cell genomics with space and time
We are interested in decoding the spatial organization and temporal dynamics of complex tissues.
Our laboratory, at the Broad Institute, sets out to build new technologies to discover where cell types are localized within intact tissues when relevant transcriptional modules are active. To do this, we are developing novel strategies at the intersection of microscopy, genomics, synthetic biology, and computational analysis.
News
2024.10.11 - Congratulations to Dawn Chen for publishing HACE on Science!! (link)
2024.08.08 - Check out our new publications about spatial reconstruction of tissue without imaging on BioRxiv (link)
2024.07.21 - Roasting tissues @ Chen lab BBQ
2023.12.14 - Come check out our publications on Nature!! Slide-tags (link) and Mouse brain (link)
2023.11.07 - Successful 1st ever Chen lab retreat @New Hampshire! Thanks everyone for making this happen!
Featured Publications
